Ceruloplasmin è un gene codificato dal simbolo CP. Altri nomi includono: Ferroxidase; CP. Ceruloplasmin ha una massa di 122.21kDa, una lunghezza di amminoacidi di 1065, ed è implicato in Aceruloplasminemia.
Offriamo 10 anticorpi contro Ceruloplasmin, allevati nel Coniglio, Capra e Sheep, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e Dot con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
Sommario di Entrez
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Specificità del tessuto
Expressed by the liver and secreted in plasma.
Coinvolgimento nella malattia
Aceruloplasminemia: An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
Somiglianze di sequenza
Belongs to the multicopper oxidase family.
Posizione cellulare
Secreted.
Colocalizes with GCP1 in secretory intracellular compartments.
