CIRBP è un gene codificato dal simbolo CIRBP. Altri nomi includono: Cold-inducible RNA-binding protein; A18 hnRNP; Glycine-rich RNA-binding protein CIRP; A18HNRNP; CIRP. CIRBP ha una massa di 18.65kDa e una lunghezza di amminoacidi di 172.
Offriamo 8 anticorpi contro CIRBP, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
Specificità del tessuto
Ubiquitous.
Modifica post-translazionale
Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).
Posizione cellulare
Nucleus > Nucleoplasm. Cytoplasm.
Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
