CLEC12A è un gene codificato dal simbolo CLEC12A. Altri nomi includono: C-type lectin domain family 12 member A; C-type lectin-like molecule 1; CLL-1; Dendritic cell-associated lectin 2; DCAL-2; Myeloid inhibitory C-type lectin-like receptor; MICL; CLL1; DCAL2. CLEC12A ha una massa di 30.76kDa e una lunghezza di amminoacidi di 265.
Offriamo 6 anticorpi contro CLEC12A, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Sommario di Entrez
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
Specificità del tessuto
Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
Modifica post-translazionale
Highly N-glycosylated. Glycosylation varies between cell types.
Posizione cellulare
Cell membrane.
Ligand binding leads to internalization.
