Anticorpi Clusterin

42 prodotti

Clusterin è un gene codificato dal simbolo CLU. Altri nomi includono: Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40,40; Ku70-binding protein 1; NA1/NA2; Sulfated glycoprotein 2; SGP-2; Testosterone-repressed prostate message 2; TRPM-2; CLU; APOJ; KUB1. Clusterin ha una massa di 52.5kDa e una lunghezza di amminoacidi di 449.

Offriamo 42 anticorpi contro Clusterin, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, PubMed:19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:12047389, PubMed:17412999, PubMed:17407782). Does not require ATP (PubMed:11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed:11123922). Does not refold proteins by itself (PubMed:11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed:21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed:2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed:20068069). Modulates NF-kappa-B transcriptional activity (PubMed:12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed:16113678, PubMed:17689225). Plays a role in the regulation of cell proliferation (PubMed:19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed:22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity).
Sommario di Entrez
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.
Specificità del tessuto
Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.
Somiglianze di sequenza
Belongs to the clusterin family.
Modifica post-translazionale
Proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen (PubMed:2387851). Proteolytic cleavage is not necessary for its chaperone activity (PubMed:25402950). All non-secreted forms are not proteolytically cleaved (PubMed:24073260). Chaperone activity of uncleaved forms is dependent on a non-reducing envoronment (PubMed:25402950).
Posizione cellulare
Secreted.

Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.
Western Blot - Anti-CLUS Antibody (C13035) - Antibodies.com
(7)
Visualizza prodotto10µg Dimensione di prova
Western Blot - Anti-Clusterin Antibody (A89399) - Antibodies.com
(5)
Western Blot - Anti-Clu Antibody (A84594) - Antibodies.com
(2)
Western Blot - Anti-Clusterin Antibody (A92263) - Antibodies.com
(2)
Western Blot - Anti-Clusterin Antibody [CLU/4723] - BSA and Azide free (A278138) - Antibodies.com
(4)
Visualizza prodottoAnticorpo monospecifico
Western Blot - Anti-CLU Antibody (A83344) - Antibodies.com
(2)
Western Blot - Anti-Clusterin Antibody [CLU/4723] (A277550) - Antibodies.com
(4)
Visualizza prodottoAnticorpo monospecifico
SDS-PAGE - Anti-Clusterin Antibody [AB-16B5] - Low endotoxin, Azide free (A323978) - Antibodies.com
(2)
Visualizza prodottoAnticorpo ricombinante
Immunohistochemistry - Anti-Clusterin Antibody [CLU/4729] - BSA and Azide free (A278140) - Antibodies.com
(4)
Visualizza prodottoAnticorpo monospecifico
Western Blot - Anti-Clusterin Antibody [CLU/4731] - BSA and Azide free (A278136) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-Clusterin Antibody [CLU/4729] (A277552) - Antibodies.com
(4)
Visualizza prodottoAnticorpo monospecifico
Western Blot - Anti-Clusterin Antibody [CLU/4731] (A277548) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Western Blot - Anti-Clusterin Antibody [CLU/4727] - BSA and Azide free (A278139) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Western Blot - Anti-Clusterin Antibody [CLU/4727] (A277551) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
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Immunohistochemistry - Anti-Clusterin Antibody [CLU/4730] - BSA and Azide free (A278135) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-Clusterin Antibody [CLU/4730] (A277547) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Western Blot - Anti-CLU Antibody (A85057) - Antibodies.com
Western Blot - Anti-Clu Antibody (A85018) - Antibodies.com
Immunohistochemistry - Anti-Clusterin Antibody [IHC546] (A324526) - Antibodies.com
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Visualizza prodottoAnticorpo ricombinante
SDS-PAGE - Anti-Clusterin Antibody [CLU/4733] - BSA and Azide free (A278137) - Antibodies.com
Flow Cytometry - Anti-Clusterin Chimeric Antibody [DMC461] - Azide free (A318729) - Antibodies.com
Visualizza prodottoAnticorpo ricombinante
SDS-PAGE - Anti-Clusterin Antibody [CLU/4733] (A277549) - Antibodies.com
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Visualizza prodottoAnticorpo ricombinante
Western blot - CLU antibody from Signalway Antibody (38241) - Antibodies.com
(2)
Western blot - Clusterin Antibody from Signalway Antibody (24428) - Antibodies.com
(2)
CLU/APOJ Antibody from Signalway Antibody (43901) - Antibodies.com
(3)
Clusterin Polyclonal Antibody from Signalway Antibody (42447) - Antibodies.com
(2)
Immunohistochemistry - CLU Antibody from Signalway Antibody (43225) - Antibodies.com
(2)
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