Anticorpi Cyclin D1

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Cyclin D1 è un gene codificato dal simbolo CCND1. Altri nomi includono: G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene; CCND1; BCL1; PRAD1. Cyclin D1 ha una massa di 33.73kDa, una lunghezza di amminoacidi di 295, ed è implicato in Multiple myeloma.

Offriamo 70 anticorpi contro Cyclin D1, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati ​​da Umano, Topo, Ratto, Scimmia, Cane, Primati e Zebrafish.

Informazioni su geni e proteine

Riepilogo UniProt
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Sommario di Entrez
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Coinvolgimento nella malattia
Multiple myeloma: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
Somiglianze di sequenza
Belongs to the cyclin family. Cyclin D subfamily.
Modifica post-translazionale
Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.
Posizione cellulare
Nucleus. Cytoplasm. Nucleus membrane.

Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
Anti-Cyclin D1 (L283) Antibody from Bioworld Technology (BS1741) - Antibodies.com
(2)
Western Blot - Anti-Cyclin D1 Antibody [ARC0300] (A306339) - Antibodies.com
(10)
Visualizza prodottoKnockout convalidato
Immunohistochemistry - Anti-Cyclin D1 Antibody [DCS-6] - BSA and Azide free (A253036) - Antibodies.com
(4)
Immunohistochemistry - Anti-Cyclin D1 Antibody [DCS-6] (A249856) - Antibodies.com
(4)
Western Blot - Anti-Cyclin D1 Antibody (A80774) - Antibodies.com
(4)
Western Blot - Anti-Cyclin D1 (phospho Thr286) Antibody (A0417) - Antibodies.com
(3)
Visualizza prodotto10µg Dimensione di prova
Flow Cytometry - Anti-Cyclin D1 Antibody [DCS-6] (A86869) - Antibodies.com
Visualizza prodotto10µg Dimensione di prova
Immunohistochemistry - Anti-Cyclin D1 Antibody [SPM587] - BSA and Azide free (A253036) - Antibodies.com
(2)
Immunohistochemistry - Anti-Cyclin D1 Antibody [SPM587] (A249856) - Antibodies.com
(2)
Western Blot - Anti-Cyclin D1 (phospho Thr286) Antibody (A305286) - Antibodies.com
(4)
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Visualizza prodotto10µg Dimensione di prova
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Immunohistochemistry - Anti-Cyclin D1 Antibody (B0417) - Antibodies.com
(2)
Visualizza prodotto10µg Dimensione di prova
Flow Cytometry - Anti-Cyclin D1 Antibody [SPM587] (PE) (A251189) - Antibodies.com
(2)
Flow Cytometry - Anti-Cyclin D1 Antibody [DCS-6] (PE) (A251147) - Antibodies.com
(2)
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/809] - BSA and Azide free (A253038) - Antibodies.com
(5)
Flow Cytometry - Anti-Cyclin D1 Antibody [DCS-6] (PE) (A86871) - Antibodies.com
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/809] (A249858) - Antibodies.com
(5)
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Visualizza prodotto10µg Dimensione di prova
Immunohistochemistry - Anti-Cyclin D1 Antibody [RM241] (A121455) - Antibodies.com
(4)
Visualizza prodottoAnticorpo ricombinante
Western Blot - Anti-Cyclin D1 Antibody (A305166) - Antibodies.com
(2)
Western Blot - Anti-Cyclin D1 Antibody (R12-2666) - Antibodies.com
Visualizza prodotto10µg Dimensione di prova
Western Blot - Anti-Cyclin D1 Antibody (A80795) - Antibodies.com
Western Blot - Anti-Cyclin D1 Antibody (B0879) - Antibodies.com
Visualizza prodotto10µg Dimensione di prova
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/2593] - BSA and Azide free (A253039) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/3370R] - BSA and Azide free (A253041) - Antibodies.com
(3)
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/3370R] (A249861) - Antibodies.com
(3)
Immunohistochemistry - Anti-Cyclin D1 Antibody - Antibodies.com (A8209)
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/2593] (A249859) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Western Blot - Anti-Cyclin D1 Antibody (A11552) - Antibodies.com
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SDS-PAGE - Anti-Cyclin D1 Antibody [CCND1/3548] (A249860) - Antibodies.com
(2)
Visualizza prodottoAnticorpo monospecifico
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Flow Cytometry - Anti-Cyclin D1 Antibody [CCND1/809] (PE) (A251151) - Antibodies.com
Western Blot - Anti-CCND1 Antibody (A85171) - Antibodies.com
Immunohistochemistry - Anti-Cyclin D1 Antibody [rCCND1/4752] - BSA and Azide free (A253034) - Antibodies.com
(2)
Visualizza prodottoAnticorpo ricombinante
SDS-PAGE - Anti-Cyclin D1 Antibody [CCND1/3548] - BSA and Azide free (A253040) - Antibodies.com
(2)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-Cyclin D1 Antibody [rCCND1/4752] (A249854) - Antibodies.com
(2)
Visualizza prodottoAnticorpo ricombinante
Flow Cytometry - Anti-Cyclin D1 Antibody - Antibodies.com (A8306)
Immunohistochemistry - Anti-Cyclin D1 Antibody [IHC452] (A324531) - Antibodies.com
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Anti-Cyclin D1 Antibody from Bioworld Technology (BS9827M) - Antibodies.com
(7)
Western blot - Cyclin D1 Polyclonal Antibody from Signalway Antibody (40803) - Antibodies.com
(2)
Cyclin D1 Antibody from Signalway Antibody (39315) - Antibodies.com
(2)
Western blot - CCND1 Antibody from Signalway Antibody (32262) - Antibodies.com
(2)
Anti-Cyclin D1 Antibody from FabGennix (CYCD1-101AP) - Antibodies.com
Anti-Cyclin D1 Antibody from FabGennix (CYCD1-121AP) - Antibodies.com
CCND1 Antibody from Signalway Antibody (31064) - Antibodies.com
(2)
Western blot - Cyclin D1 (Phospho-Thr288) Antibody from Signalway Antibody (12597) - Antibodies.com

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