DGAT1 è un gene codificato dal simbolo DGAT1. Altri nomi includono: Diacylglycerol O-acyltransferase 1; ACAT-related gene product 1; Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Diglyceride acyltransferase; AGRP1; DGAT. DGAT1 ha una massa di 55.28kDa, una lunghezza di amminoacidi di 488, ed è implicato in Diarrhea 7, protein-losing enteropathy type.
Offriamo 6 anticorpi contro DGAT1, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.
Sommario di Entrez
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases.
Coinvolgimento nella malattia
Diarrhea 7, protein-losing enteropathy type: A life-threatening disease characterized by severe, intractable, watery diarrhea.
Somiglianze di sequenza
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Posizione cellulare
Endoplasmic reticulum membrane.
