EB2 è un gene codificato dal simbolo MAPRE2. Altri nomi includono: Microtubule-associated protein RP/EB family member 2; APC-binding protein End-binding protein 2; MAPRE2; RP1. EB2 ha una massa di 37.03kDa, una lunghezza di amminoacidi di 327, ed è implicato in Skin creases, congenital symmetric circumferential, 2.
Offriamo 3 anticorpi contro EB2, allevati nel Coniglio e Ratto, che sono adatti per WB, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
Sommario di Entrez
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants.
Specificità del tessuto
Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
Coinvolgimento nella malattia
Skin creases, congenital symmetric circumferential, 2: An autosomal dominant disease characterized by multiple, symmetric, circumferential rings of folded skin, affecting primarily the limbs. Affected individuals also exhibit intellectual disability, cleft palate, and dysmorphic features.
Somiglianze di sequenza
Belongs to the MAPRE family.
Posizione cellulare
Cytoplasm > Cytoskeleton.
Associated with the microtubule network. Accumulates at the plus end of microtubules.
