Factor XIIIa è un gene codificato dal simbolo F13A1. Altri nomi includono: Coagulation factor XIII A chain; Coagulation Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain; F13A1; F13A. Factor XIIIa ha una massa di 83.27kDa, una lunghezza di amminoacidi di 732, ed è implicato in Factor XIII subunit A deficiency.
Offriamo 23 anticorpi contro Factor XIIIa, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Scimmia e Gatto.
Informazioni su geni e proteine
Riepilogo UniProt
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Sommario di Entrez
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Coinvolgimento nella malattia
Factor XIII subunit A deficiency: An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
Somiglianze di sequenza
Belongs to the transglutaminase superfamily. Transglutaminase family.
Modifica post-translazionale
The activation peptide is released by thrombin.
Posizione cellulare
Cytoplasm. Secreted.
Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
