FCRL2 è un gene codificato dal simbolo FCRL2. Altri nomi includono: Fc receptor-like protein 2; FcR-like protein 2; Fc receptor homolog 2; FcRH2; IFGP family protein 4; Immunoglobulin receptor translocation-associated protein 4; SH2 domain-containing phosphatase anchor protein 1; FCRH2; IFGP4; IRTA4; SPAP1. FCRL2 ha una massa di 55.54kDa e una lunghezza di amminoacidi di 508.
Offriamo 2 anticorpi contro FCRL2, allevati nel Topo e Capra, che sono adatti per WB, ELISA e Citometria a Flusso con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
May have an regulatory role in normal and neoplastic B cell development.
Sommario di Entrez
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Specificità del tessuto
Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level).
Modifica post-translazionale
Isoform 2 is N- and O-glycosylated, and phosphorylated.
Posizione cellulare
Cell membrane.
