Fibrillarin è un gene codificato dal simbolo FBL. Altri nomi includono: rRNA 2'-O-methyltransferase 34 kDa nucleolar scleroderma antigen; Histone-glutamine methyltransferase; FBL; FIB1; FLRN. Fibrillarin ha una massa di 33.78kDa e una lunghezza di amminoacidi di 321.
Offriamo 11 anticorpi contro Fibrillarin, allevati nel Coniglio, Topo, Capra e Pollo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Scimmia, C. elegans, Cane, Drosofila, Cavallo, S. cerevisiae e Zebrafish.
Informazioni su geni e proteine
Riepilogo UniProt
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:24352239, PubMed:30540930). Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:30540930). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239, PubMed:30540930).
Sommario di Entrez
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
Somiglianze di sequenza
Belongs to the methyltransferase superfamily. Fibrillarin family.
Modifica post-translazionale
Ubiquitinated. Ubiquitination leads to proteasomal degradation (PubMed:19208757). Deubiquitinated by USP36 (PubMed:19208757).
Posizione cellulare
Nucleus > Nucleolus.
Fibrillar region of the nucleolus.
