GAD65 è un gene codificato dal simbolo GAD2. Comunemente indicato anche come: Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform; GAD2. GAD65 ha una massa di 65.41kDa e una lunghezza di amminoacidi di 585.
Offriamo 25 anticorpi contro GAD65, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e RIA con campioni derivati da Umano, Topo, Ratto e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
Catalyzes the production of GABA.
Sommario di Entrez
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Somiglianze di sequenza
Belongs to the group II decarboxylase family.
Modifica post-translazionale
Phosphorylated; which does not affect kinetic parameters or subcellular location.
Posizione cellulare
Cytoplasm > Cytosol. Cytoplasmic vesicle. Cell junction > Synapse > Presynaptic cell membrane. Golgi apparatus membrane.
Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
