GATA3 è un gene codificato dal simbolo GATA3. Comunemente indicato anche come: Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3. GATA3 ha una massa di 47.92kDa, una lunghezza di amminoacidi di 443, ed è implicato in Hypoparathyroidism, sensorineural deafness, and renal disease.
Offriamo 42 anticorpi contro GATA3, allevati nel Coniglio, Topo, Capra e Ratto, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso, IP e ChIP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.
Sommario di Entrez
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.
Specificità del tessuto
T-cells and endothelial cells.
Coinvolgimento nella malattia
Hypoparathyroidism, sensorineural deafness, and renal disease: A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia.
Posizione cellulare
Nucleus.
