GNAT2 è un gene codificato dal simbolo GNAT2. Comunemente indicato anche come: Guanine nucleotide-binding protein G(t) subunit alpha-2; Transducin alpha-2 chain; GNATC. GNAT2 ha una massa di 40.18kDa, una lunghezza di amminoacidi di 354, ed è implicato in Achromatopsia 4.
Offriamo 5 anticorpi contro GNAT2, allevati nel Coniglio, che sono adatti per WB, ELISA e ICC/IF con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Sommario di Entrez
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones.
Specificità del tessuto
Retinal rod outer segment.
Coinvolgimento nella malattia
Achromatopsia 4: An ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus.
Somiglianze di sequenza
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Posizione cellulare
Cell projection > Cilium > Photoreceptor outer segment. Photoreceptor inner segment.
Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light.
