GOLPH2 è un gene codificato dal simbolo GOLM1. Comunemente indicato anche come: Golgi membrane protein 1; Golgi membrane protein GP73; Golgi phosphoprotein 2; GOLM1; C9orf155. GOLPH2 ha una massa di 45.33kDa e una lunghezza di amminoacidi di 401.
Offriamo 10 anticorpi contro GOLPH2, allevati nel Coniglio, Topo, Capra e Human, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
Unknown. Cellular response protein to viral infection.
Sommario di Entrez
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene.
Specificità del tessuto
Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.
Somiglianze di sequenza
Belongs to the GOLM1/CASC4 family.
Modifica post-translazionale
Glycosylated.
Posizione cellulare
Golgi apparatus > cis-Golgi network membrane.
Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
