GRF2 è un gene codificato dal simbolo RAPGEF1. Comunemente indicato anche come: Rap guanine nucleotide exchange factor 1; CRK SH3-binding GNRP; Guanine nucleotide-releasing factor 2; Protein C3G; RAPGEF1. GRF2 ha una massa di 120.55kDa e una lunghezza di amminoacidi di 1077.
Offriamo 7 anticorpi contro GRF2, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e ChIP con campioni derivati da Umano, Topo, Ratto, Scimmia e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.
Sommario di Entrez
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Specificità del tessuto
Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.
Modifica post-translazionale
Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor.
Posizione cellulare
Early endosome.
