GRK1 è un gene codificato dal simbolo GRK1. Comunemente indicato anche come: Rhodopsin kinase RK; G protein-coupled receptor kinase 1; RHOK. GRK1 ha una massa di 63.53kDa, una lunghezza di amminoacidi di 563, ed è implicato in Night blindness, congenital stationary, Oguchi type 2.
Offriamo 11 anticorpi contro GRK1, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).
Sommario di Entrez
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation.
Specificità del tessuto
Retinal-specific. Expressed in rods and cones cells.
Coinvolgimento nella malattia
Night blindness, congenital stationary, Oguchi type 2: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Modifica post-translazionale
Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.
Posizione cellulare
Membrane. Cell projection > Cilium > Photoreceptor outer segment.
Subcellular location is not affected by light or dark conditions.
