GST è un gene codificato dal simbolo GSTA1. Comunemente indicato anche come: Glutathione S-transferase A1; 13-hydroperoxyoctadecadienoate peroxidase; Androst-5-ene-3,17-dione isomerase HA subunit 1 class-alpha member 1-epsilonA1-1; GTH1A1. GST ha una massa di 25.63kDa e una lunghezza di amminoacidi di 222.
Offriamo 27 anticorpi contro GST, allevati nel Coniglio, Topo, Capra e Ratto, che sono adatti per WB, IHC, ELISA, ICC/IF, IP, Dot e ChIP con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).
Sommario di Entrez
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants.
Specificità del tessuto
Liver.
Somiglianze di sequenza
Belongs to the GST superfamily. Alpha family.
Posizione cellulare
Cytoplasm.
