Histone H2B è un gene codificato dal simbolo H2BC12. Comunemente indicato anche come: Histone H2B type 1-K; H2B K; HIRA-interacting protein 1; H2BC12; H2BFT; HIRIP1; HIST1H2BK. Histone H2B ha una massa di 13.89kDa e una lunghezza di amminoacidi di 126.
Offriamo 42 anticorpi contro Histone H2B, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e ChIP con campioni derivati da Umano, Topo, Ratto, Scimmia e S. pombe.
Informazioni su geni e proteine
Riepilogo UniProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Somiglianze di sequenza
Belongs to the histone H2B family.
Modifica post-translazionale
Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
Posizione cellulare
Nucleus. Chromosome.
