Hormone sensitive lipase è un gene codificato dal simbolo LIPE. Comunemente indicato anche come: Hormone-sensitive lipase; HSL; LIPE. Hormone sensitive lipase ha una massa di 116.6kDa, una lunghezza di amminoacidi di 1076, ed è implicato in Lipodystrophy, familial partial, 6.
Offriamo 12 anticorpi contro Hormone sensitive lipase, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Sommario di Entrez
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.
Coinvolgimento nella malattia
Lipodystrophy, familial partial, 6: A form of lipodystrophy characterized by abnormal subcutaneous fat distribution. Affected individuals have increased visceral fat, impaired lipolysis, dyslipidemia, hepatic steatosis, systemic insulin resistance, and diabetes. Some patients manifest muscular dystrophy.
Somiglianze di sequenza
Belongs to the 'GDXG' lipolytic enzyme family.
Modifica post-translazionale
Phosphorylation by AMPK may block translocation to lipid droplets.
Posizione cellulare
Cell membrane. Membrane > Caveola. Cytoplasm > Cytosol.
Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.
