IL18 è un gene codificato dal simbolo IL18. Comunemente indicato anche come: Interleukin-18; IL-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; IGIF; IL1F4. IL18 ha una massa di 22.33kDa e una lunghezza di amminoacidi di 193.
Offriamo 23 anticorpi contro IL18, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e IP con campioni derivati da Umano, Topo, Ratto, Maiale, Cane, Gatto e Cavallo.
Informazioni su geni e proteine
Riepilogo UniProt
A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).
Sommario di Entrez
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Somiglianze di sequenza
Belongs to the IL-1 family.
Modifica post-translazionale
The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.
Posizione cellulare
Secreted.
