ITIH1 è un gene codificato dal simbolo ITIH1. Comunemente indicato anche come: Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; Inter-alpha-trypsin inhibitor complex component III; Serum-derived hyaluronan-associated protein; SHAP; IGHEP1. ITIH1 ha una massa di 101.39kDa e una lunghezza di amminoacidi di 911.
Offriamo 2 anticorpi contro ITIH1, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Sommario di Entrez
This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3.
Somiglianze di sequenza
Belongs to the ITIH family.
Modifica post-translazionale
Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
Posizione cellulare
Secreted.
