JAK1 è un gene codificato dal simbolo JAK1. Comunemente indicato anche come: Tyrosine-protein kinase Janus kinase 1; JAK-1AB. JAK1 ha una massa di 133.28kDa e una lunghezza di amminoacidi di 1154.
Offriamo 14 anticorpi contro JAK1, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).
Sommario di Entrez
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants.
Specificità del tessuto
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Modifica post-translazionale
Autophosphorylated (PubMed:7615558). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529).
Posizione cellulare
Endomembrane system.
Wholly intracellular, possibly membrane associated.
