Anticorpi JMJD6

7 prodotti

JMJD6 è un gene codificato dal simbolo JMJD6. Comunemente indicato anche come: Bifunctional arginine demethylase and lysyl-hydroxylase Histone arginine demethylase JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase Peptide-lysine 5-dioxygenase Phosphatidylserine receptor; Protein PTDSR; KIAA0585; PSR; PTDSR. JMJD6 ha una massa di 46.46kDa e una lunghezza di amminoacidi di 403.

Offriamo 7 anticorpi contro JMJD6, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ICC/IF, IP e ChIP con campioni derivati ​​da Umano, Topo, Ratto e Cane.

Informazioni su geni e proteine

Riepilogo UniProt
Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:24498420, PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24498420, PubMed:24360279). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002).
Sommario di Entrez
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells.
Somiglianze di sequenza
Belongs to the JMJD6 family.
Modifica post-translazionale
Hydroxylates its own N-terminus; hydroxylation is required for homooligomerization.
Posizione cellulare
Nucleus > Nucleoplasm. Nucleus > Nucleolus. Cytoplasm.

Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
Immunohistochemistry - Anti-JMJD6 Antibody (A307558) - Antibodies.com
Western blot - JMJD6 Antibody from Signalway Antibody (33079) - Antibodies.com
(2)
Western blot - JMJD6 Antibody from Signalway Antibody (24962) - Antibodies.com
(2)
Segnaposto immagine Antibodies.com - Scopri di più spendendo meno
JMJD6 (N-term) Monoclonal Antibody from Signalway Antibody (27005) - Antibodies.com
(2)
PSR antibody from Signalway Antibody (22697) - Antibodies.com
(2)
Anti-JMJD6 (N-terminus) Antibody from Bioworld Technology (MB0100) - Antibodies.com
(2)

Mostra 1-7 di 7 prodotti

Filtri Menù Principale Contattaci 0Check-out
Inizio pagina