MARCKS è un gene codificato dal simbolo MARCKS. Comunemente indicato anche come: Myristoylated alanine-rich C-kinase substrate; Protein kinase C substrate, 80 kDa protein, light chain; 80K-L protein; MACS; PRKCSL. MARCKS ha una massa di 31.56kDa e una lunghezza di amminoacidi di 332.
Offriamo 19 anticorpi contro MARCKS, allevati nel Coniglio, Topo e Pollo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Sommario di Entrez
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
Somiglianze di sequenza
Belongs to the MARCKS family.
Modifica post-translazionale
Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.
Posizione cellulare
Cytoplasm > Cytoskeleton. Membrane.
