Mast Cell Tryptase è un gene codificato dal simbolo TPSAB1. Comunemente indicato anche come: Tryptase alpha/beta-1; Tryptase-1; Tryptase I; Tryptase alpha-1; TPSAB1; TPS1; TPS2; TPSB1. Mast Cell Tryptase ha una massa di 30.52kDa e una lunghezza di amminoacidi di 275.
Offriamo 11 anticorpi contro Mast Cell Tryptase, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto, Scimmia, Cane e Gatto.
Informazioni su geni e proteine
Riepilogo UniProt
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).
Sommario di Entrez
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Specificità del tessuto
Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).
Somiglianze di sequenza
Belongs to the peptidase S1 family. Tryptase subfamily.
Posizione cellulare
Secreted.
Released from the secretory granules upon mast cell activation.
