MCL1 è un gene codificato dal simbolo MCL1. Comunemente indicato anche come: Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1/EAT; BCL2L3. MCL1 ha una massa di 37.34kDa e una lunghezza di amminoacidi di 350.
Offriamo 23 anticorpi contro MCL1, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Sommario di Entrez
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
Somiglianze di sequenza
Belongs to the Bcl-2 family.
Modifica post-translazionale
Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
Posizione cellulare
Membrane. Cytoplasm. Mitochondrion. Nucleus > Nucleoplasm.
Cytoplasmic, associated with mitochondria.
