MCM7 è un gene codificato dal simbolo MCM7. Comunemente indicato anche come: DNA replication licensing factor CDC47 homolog; P1.1-MCM3; CDC47; MCM2. MCM7 ha una massa di 81.31kDa e una lunghezza di amminoacidi di 719.
Offriamo 23 anticorpi contro MCM7, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso, IP e ChIP con campioni derivati da Umano, Topo, Ratto, Criceto e S. pombe.
Informazioni su geni e proteine
Riepilogo UniProt
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
Sommario di Entrez
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Somiglianze di sequenza
Belongs to the MCM family.
Modifica post-translazionale
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
Posizione cellulare
Nucleus.
