MelanA è un gene codificato dal simbolo MLANA. Comunemente indicato anche come: Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; MLANA; MART1. MelanA ha una massa di 13.16kDa e una lunghezza di amminoacidi di 118.
Offriamo 44 anticorpi contro MelanA, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ICC/IF, Citometria a Flusso e ChIP con campioni derivati da Umano, Topo, Ratto, Cane e Cavallo.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Specificità del tessuto
Expression is restricted to melanoma and melanocyte cell lines and retina.
Modifica post-translazionale
Acylated.
Posizione cellulare
Endoplasmic reticulum membrane. Golgi apparatus. Golgi apparatus > trans-Golgi network membrane. Melanosome.
Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
