Metallothionein è un gene codificato dal simbolo MT2A. Comunemente indicato anche come: Metallothionein-2; MT-2-2A-II; MT-II; MT2A; CES1; MT2. Metallothionein ha una massa di 6.04kDa e una lunghezza di amminoacidi di 61.
Offriamo 9 anticorpi contro Metallothionein, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Sommario di Entrez
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity.
Somiglianze di sequenza
Belongs to the metallothionein superfamily. Type 1 family.
