MLK2 è un gene codificato dal simbolo MAP3K10. Comunemente indicato anche come: Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST; MAP3K10; MST. MLK2 ha una massa di 103.69kDa e una lunghezza di amminoacidi di 954.
Offriamo 11 anticorpi contro MLK2, allevati nel Coniglio e Pollo, che sono adatti per WB, IHC, ELISA e Dot con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Activates the JUN N-terminal pathway.
Sommario di Entrez
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Specificità del tessuto
Expressed in brain and skeletal muscle.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Modifica post-translazionale
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
