MMP7 è un gene codificato dal simbolo MMP7. Comunemente indicato anche come: Matrilysin; Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase; MPSL1; PUMP1. MMP7 ha una massa di 29.68kDa e una lunghezza di amminoacidi di 267.
Offriamo 12 anticorpi contro MMP7, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e ChIP con campioni derivati da Umano, Topo, Ratto e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Sommario di Entrez
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.
Somiglianze di sequenza
Belongs to the peptidase M10A family.
Posizione cellulare
Secreted > Extracellular space > Extracellular matrix.
