MTMR3 è un gene codificato dal simbolo MTMR3. Comunemente indicato anche come: Myotubularin-related protein 3; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; Zinc finger FYVE domain-containing protein 10; KIAA0371; ZFYVE10. MTMR3 ha una massa di 133.62kDa e una lunghezza di amminoacidi di 1198.
Offriamo 1 anticorpi contro MTMR3, allevati nel Coniglio, che sono adatti per WB e ICC/IF con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).
Sommario di Entrez
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
Somiglianze di sequenza
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Posizione cellulare
Cytoplasm. Membrane.
