N Cadherin è un gene codificato dal simbolo CDH2. Comunemente indicato anche come: Cadherin-2; CDw325; Neural cadherin; N-cadherin; CDH2; CDHN; NCAD. N Cadherin ha una massa di 99.81kDa e una lunghezza di amminoacidi di 906.
Offriamo 35 anticorpi contro N Cadherin, allevati nel Coniglio, Topo, Capra e Ratto, che sono adatti per WB, IHC, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Scimmia, Pollo e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Sommario di Entrez
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone.
Modifica post-translazionale
Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).
Posizione cellulare
Cell membrane. Cell membrane > Sarcolemma. Cell junction. Cell surface.
Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes.
