NAPSIN A è un gene codificato dal simbolo NAPSA. Comunemente indicato anche come: Napsin-A; Aspartyl protease 4; ASP4; Napsin-1; TA01/TA02; NAPSA; NAP1; NAPA. NAPSIN A ha una massa di 45.39kDa e una lunghezza di amminoacidi di 420.
Offriamo 46 anticorpi contro NAPSIN A, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso, IP e ChIP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May be involved in processing of pneumocyte surfactant precursors.
Sommario di Entrez
This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma.
Specificità del tessuto
Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.
Somiglianze di sequenza
Belongs to the peptidase A1 family.
Posizione cellulare
Secreted.
