NCF1 è un gene codificato dal simbolo NCF1. Comunemente indicato anche come: Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox; NOXO2; SH3PXD1A. NCF1 ha una massa di 44.68kDa, una lunghezza di amminoacidi di 390, ed è implicato in Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive.
Offriamo 28 anticorpi contro NCF1, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo, Ratto e Maiale.
Informazioni su geni e proteine
Riepilogo UniProt
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Sommario di Entrez
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.
Specificità del tessuto
Detected in peripheral blood monocytes and neutrophils (at protein level).
Coinvolgimento nella malattia
Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
Modifica post-translazionale
Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity.
Posizione cellulare
Cytoplasm > Cytosol. Membrane.
