NeuN è un gene codificato dal simbolo RBFOX3. Comunemente indicato anche come: RNA binding protein fox-1 homolog 3; Fox-1 homolog C; Neuronal nuclei antigen antigen; RBFOX3. NeuN ha una massa di 33.87kDa e una lunghezza di amminoacidi di 312.
Offriamo 31 anticorpi contro NeuN, allevati nel Coniglio, Topo, Capra e Pollo, che sono adatti per WB, IHC, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).
Sommario di Entrez
This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Posizione cellulare
Nucleus. Cytoplasm.
Largely restricted to neuronal nuclei. However, significant cytoplasmic localization in neurons from brains from HIV-infected individuals with cognitive impairment.
