Neurotrophin 4 è un gene codificato dal simbolo NTF4. Comunemente indicato anche come: Neurotrophin-4; NT-4; Neurotrophin-5; NT-5; Neutrophic factor 4; NTF4; NTF5. Neurotrophin 4 ha una massa di 22.43kDa, una lunghezza di amminoacidi di 210, ed è implicato in Glaucoma 1, open angle, O.
Offriamo 6 anticorpi contro Neurotrophin 4, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Target-derived survival factor for peripheral sensory sympathetic neurons.
Sommario di Entrez
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.
Specificità del tessuto
Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
Coinvolgimento nella malattia
Glaucoma 1, open angle, O: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
Somiglianze di sequenza
Belongs to the NGF-beta family.
Posizione cellulare
Secreted.
