OB Cadherin è un gene codificato dal simbolo CDH11. Comunemente indicato anche come: Cadherin-11; OSF-4; Osteoblast cadherin; OB-cadherin; CDH11. OB Cadherin ha una massa di 87.97kDa, una lunghezza di amminoacidi di 796, ed è implicato in Elsahy-Waters syndrome.
Offriamo 11 anticorpi contro OB Cadherin, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto e Zebrafish.
Informazioni su geni e proteine
Riepilogo UniProt
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Sommario di Entrez
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
Specificità del tessuto
Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
Coinvolgimento nella malattia
Elsahy-Waters syndrome: An autosomal recessive syndrome characterized by moderate mental retardation, hypospadias and characteristic craniofacial morphology, which includes brachycephaly, facial asymmetry, exotropia, hypertelorism, telechantus, broad nose, concave nasal ridge, underdeveloped mid-face, prognathism, and radicular dentin dysplasia.
Posizione cellulare
Cell membrane.
