PDE8A è un gene codificato dal simbolo PDE8A. È noto anche come High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A. PDE8A ha una massa di 93.3kDa e una lunghezza di amminoacidi di 829.
Offriamo 12 anticorpi contro PDE8A, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo, Ratto, Bovino e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).
Sommario di Entrez
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
Somiglianze di sequenza
Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
Modifica post-translazionale
Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity.
