PIGR è un gene codificato dal simbolo PIGR. Comunemente indicato anche come: Polymeric immunoglobulin receptor; Hepatocellular carcinoma-associated protein TB6. PIGR ha una massa di 83.28kDa e una lunghezza di amminoacidi di 764.
Offriamo 3 anticorpi contro PIGR, allevati nel Coniglio e Ratto, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Sommario di Entrez
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.
Modifica post-translazionale
N-glycosylation is not necessary for Ig binding.
Posizione cellulare
Cell membrane.
