POU4F3 è un gene codificato dal simbolo POU4F3. Comunemente indicato anche come: POU domain, class 4, transcription factor 3; Brain-specific homeobox/POU domain protein 3C; Brain-3C; BRN3C. POU4F3 ha una massa di 37.05kDa, una lunghezza di amminoacidi di 338, ed è implicato in Deafness, autosomal dominant, 15.
Offriamo 5 anticorpi contro POU4F3, allevati nel Coniglio e Capra, che sono adatti per WB e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity).
Sommario di Entrez
This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15.
Specificità del tessuto
Brain. Seems to be specific to the retina.
Coinvolgimento nella malattia
Deafness, autosomal dominant, 15: A form of non-syndromic hearing loss with variable phenotype in terms of age at onset, levels of progression, and shape of audiograms.
Somiglianze di sequenza
Belongs to the POU transcription factor family. Class-4 subfamily.
Posizione cellulare
Nucleus. Cytoplasm.
Preferentially localized in the nucleus.
