PPP2R5A è un gene codificato dal simbolo PPP2R5A. Comunemente indicato anche come: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PP2A B subunit isoform B'-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PR61alpha; PP2A B subunit isoform R5-alpha. PPP2R5A ha una massa di 56.19kDa e una lunghezza di amminoacidi di 486.
Offriamo 6 anticorpi contro PPP2R5A, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Sommario di Entrez
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene.
Specificità del tessuto
Widely expressed with the highest expression in heart and skeletal muscle.
Somiglianze di sequenza
Belongs to the phosphatase 2A regulatory subunit B56 family.
Modifica post-translazionale
Phosphorylated on serine residues.
Posizione cellulare
Cytoplasm. Nucleus. Chromosome > Centromere.
From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.
