Renin è un gene codificato dal simbolo REN. È noto anche come: Angiotensinogenase; REN. Renin ha una massa di 45.06kDa, una lunghezza di amminoacidi di 406, ed è implicato nella malattia: Renal tubular dysgenesis; Familial juvenile hyperuricemic nephropathy 2.
Offriamo 6 anticorpi contro Renin, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Sommario di Entrez
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
Coinvolgimento nella malattia
Renal tubular dysgenesis: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Familial juvenile hyperuricemic nephropathy 2: A renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
Somiglianze di sequenza
Belongs to the peptidase A1 family.
Posizione cellulare
Secreted. Membrane.
Associated to membranes via binding to ATP6AP2.
