RIP140 è un gene codificato dal simbolo NRIP1. È noto anche come: Nuclear receptor-interacting protein 1; Nuclear factor Receptor-interacting protein 140; NRIP1. RIP140 ha una massa di 126.94kDa, una lunghezza di amminoacidi di 1158, ed è implicato in Congenital anomalies of kidney and urinary tract 3.
Offriamo 14 anticorpi contro RIP140, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e ChIP con campioni derivati da Umano, Topo, Ratto, Scimmia e Pollo.
Informazioni su geni e proteine
Riepilogo UniProt
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549).
Sommario di Entrez
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor.
Coinvolgimento nella malattia
Congenital anomalies of kidney and urinary tract 3: A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children. CAKUT3 inheritance is autosomal dominant.
Modifica post-translazionale
Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.
Posizione cellulare
Nucleus.
Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
