Secretogranin 3 è un gene codificato dal simbolo SCG3. È noto anche come: Secretogranin-3; Secretogranin III; SgIII; SCG3. Secretogranin 3 ha una massa di 53.01kDa e una lunghezza di amminoacidi di 468.
Offriamo 4 anticorpi contro Secretogranin 3, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827).
Sommario di Entrez
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Expressed in brain, heart, kidney, liver and skeletal muscle.
Modifica post-translazionale
O-glycosylated.
Posizione cellulare
Cytoplasmic vesicle > Secretory vesicle. Cytoplasmic vesicle > Secretory vesicle membrane. Secreted.
Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts.
