Semaphorin 4D è un gene codificato dal simbolo SEMA4D. È noto anche come: Semaphorin-4D; A8; BB18; GR3; SEMA4D; C9orf164; CD100; SEMAJ. Semaphorin 4D ha una massa di 96.15kDa e una lunghezza di amminoacidi di 862.
Offriamo 9 anticorpi contro Semaphorin 4D, allevati nel Coniglio e Topo, che sono adatti per WB, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo, Ratto, Scimmia e Primati.
Informazioni su geni e proteine
Riepilogo UniProt
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).
Specificità del tessuto
Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
Somiglianze di sequenza
Belongs to the semaphorin family.
Posizione cellulare
Cell membrane.
