SERCA1 ATPase è un gene codificato dal simbolo ATP2A1. È noto anche come: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; ATP2A1. SERCA1 ATPase ha una massa di 110.25kDa, una lunghezza di amminoacidi di 1001, ed è implicato in Brody myopathy.
Offriamo 6 anticorpi contro SERCA1 ATPase, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677).
Sommario di Entrez
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.
Specificità del tessuto
Skeletal muscle, fast twitch muscle (type II) fibers.
Coinvolgimento nella malattia
Brody myopathy: A disorder of muscle function that is characterized by painless muscle cramping and exercise-induced impairment of muscle relaxation.
Somiglianze di sequenza
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
Posizione cellulare
Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane.
