SMC2 è un gene codificato dal simbolo SMC2. È noto anche come: Structural maintenance of chromosomes protein 2; SMC protein 2; Chromosome-associated protein E; hCAP-E; XCAP-E homolog; CAPEL1. SMC2 ha una massa di 135.66kDa e una lunghezza di amminoacidi di 1197.
Offriamo 5 anticorpi contro SMC2, allevati nel Coniglio, Capra e Ratto, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Somiglianze di sequenza
Belongs to the SMC family. SMC2 subfamily.
Posizione cellulare
Nucleus. Cytoplasm. Chromosome.
In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
