SMCR7L è un gene codificato dal simbolo MIEF1. È noto anche come: Mitochondrial dynamics protein MID51; Mitochondrial dynamics protein of 51 kDa; Mitochondrial elongation factor 1; Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like; SMCR7-like protein; MIEF1; MID51. SMCR7L ha una massa di 51.29kDa e una lunghezza di amminoacidi di 463.
Offriamo 1 anticorpi contro SMCR7L, allevati nel Coniglio, che sono adatti per WB con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.
Specificità del tessuto
Expression is relatively high in heart, skeletal muscle, pancreas and kidney.
Somiglianze di sequenza
Belongs to the SMCR7 family.
Posizione cellulare
Mitochondrion outer membrane.
