STK39 è un gene codificato dal simbolo STK39. È noto anche come: STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; DCHT; Serine/threonine-protein kinase 39; SPAK. STK39 ha una massa di 59.47kDa e una lunghezza di amminoacidi di 545.
Offriamo 17 anticorpi contro STK39, allevati nel Coniglio e Capra, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.
Sommario di Entrez
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.
Specificità del tessuto
Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Modifica post-translazionale
Phosphorylated at Ser-309 by PRKCQ (PubMed:14988727). Autophosphorylation at Thr-231 positively regulates its activity (By similarity).
Posizione cellulare
Cytoplasm. Nucleus.
Nucleus when caspase-cleaved.
